Abstract
The aim of the research is to study the activity of hydrolytic enzymes in epithelium of rats’ trachea under total cooling of the organism. The analysis of the obtained data showed that with a daily three hour total cold exposure of rabbits during 28 days at the temperature of -25~-28ºC, a significant increase in the activity of acidic phosphomonoesterase at the apical pole of the epithelial cells of the tracheal mucosa was observed. Under these experimental conditions, alkaline phosphatase is active in the basal pole of the epithelium and in granules of mast cells migrating through the tracheal epithelium into the lumen of the trachea. There are reasons to believe that the continuation of the adverse effect of low temperatures leads to deep and persistent disturbance of the enzymatic organization of hydrolytic enzymes of epithelial cells, pronounced destabilization of lysosome membranes and the development of destructive changes in ciliate epitheliocytes.
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