Abstract
Oxidative stress underlies the formation of the pathology of cardiovascular system in young athletes. Its potential role in the pathogenesis of myocardial remodeling in young athletes has been discussed. The paper is devoted to the study of the changes of free radical oxidation in the body by the method of chemiluminescence and antioxidant effect on the functional state of the cardiovascular system. The results of clinical studies on the antioxidant effect of polydihidroxyphenilenthiosulfonate sodium («Hypoxen») in vitro, namely the addition of a substance in a simple model systems that mimic the most common reactions of free radical oxidation in the organism, such as formation of reactive oxygen species and lipid peroxidation. It has been found in this study that concentration of free radicals in the blood in athletes with physiological manifestations of athlete´s heart and signs of stress cardiomyopathy has been increased. After administration of Hypoxen in vivo the concentration of free radicals in the athlete’s blood has been found to be reduced. In assessing the functional state of the cardiovascular system administration of Hypoxen resulted in the improved physical performance in young athletes. Maintaining of free radical oxidation processes at the optimal levels contributes to timely prevention of stress cardiomyopathy.
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