Эпидемиологические, гистопатологические и иммуногистохимические особенности опухолей яичников на севере Центрального региона Алжира

Abstract

Introduction. Ovarian tumors (OT) are the leading cause of death from gynecological cancer. Aim. Studying of epidemiological, histopathological, and immunohistochemical profile of OT in the North-Central region of Algeria. Materials and methods. An epidemiological and histopathological analysis of OT that were diagnosed over a period of 32 months from January 2018 to August 2020 in Algiers was carried out. It grouped all the histologically confirmed cases in the Pathological Anatomy and Cytology Department of the Hussein Dey Hospital during the study period. Through this work, we collected 110 cases of OT. Among this total, 26 cases (23.63%) were represented by functional cysts and 7 cases (6.36%) by borderline epithelial tumors excluded from our work. Only OT (benign and malignant) were studied. On the epidemiological level, we were interested in the age factors and distribution by year of study, and on the anatomopathological level, we dealt with the topography, macroscopic and histological aspects of these tumors. Results. An average age of the patients with OT was 39.99 years, with extremes of 16 years and 88 years, and the most affected age was that of 15–30 years with 29 cases. Both ovaries were affected in 4.47% of cases. The study revealed that 79% of OT were benign, and epithelial tumors were more frequent (69% of cases). In this type, serous cystadenoma was most common among benign epithelial tumors (70.45%), and cystadenocarcinoma was most dominant among malignant epithelial tumors (80%). Mature teratoma represented 85.71% of germ cell tumors in our series, and fibrothecoma represented 55.55% of sex cord-stromal tumors cases. The latter predominated in older patients (46–60 years. Conclusion. The authors recommend to broaden this study over several hospital structures with the inclusion of other parameters for a better understanding and determining the criteria of this disease.