Таблетки или лишение сна? Депривация сна как вид терапевтического вмешательства в психиатрии

Andrey Viktorovich Antsyborov,Irina Vladimirovna Dubatova,Anna Valerievna Kalinchuk

doi:10.21661/r-551967

Abstract

In recent decades, sleep deprivation has evolved from a single experimental data set to the status of an effective and affordable therapeutic intervention used in daily clinical practice. The mechanism of action of this method is aimed at the same neurotransmitter systems and brain regions as antidepressants. As in the case of pharmacotherapy for sleep deprivation, it should be used under close supervision of a physician. Clinical effects with sleep deprivation are achieved much faster than with psychopharmacotherapy, but they are not long-term in nature. It is possible to improve the results using a combination of pharmacotherapy and sleep deprivation. The use of sleep deprivation in clinical conditions is aimed primarily at preventing depression and its recurrence, as well as in cases resistant to pharmacotherapy. In modern conditions, the method of sleep deprivation is a significant alternative to traditional approaches to therapy of depression.

Highlights

Same neurotransmitter systems and brain regions as antidepressants
As in the case of pharmacotherapy for sleep deprivation, it should be used under close supervision of a physician
Clinical effects with sleep deprivation are achieved much faster than with psychopharmacotherapy, but they are not long-term in nature

Summary

Introduction

Same neurotransmitter systems and brain regions as antidepressants. As in the case of pharmacotherapy for sleep deprivation, it should be used under close supervision of a physician. Однако большая часть результатов исследований демонстрирует, что полная (тотальная) депривация сна (TSD) более эффективна, чем методика частичной депривации (PSD) [7; 8; 15; 22]. Быстрота клинического ответа при применении депривации сна Данные клинических исследований, полученные на большом массиве пациентов с депрессией в большинстве диагностических рубрик, демонстрируют значимые клинические ответы на следующий день после завершения полной (тотальной) депривации сна (TSD) [6; 17; 58; 59].

Results

Conclusion