Сравнительный анализ мониторинга биомаркеров воспаления у беременных с преждевременным разрывом плодных оболочек

Abstract

Aim: to qualitatively improve the approach to timely detection of purulent septic compli-cations in pregnant women with a long anhydrous interval in the setting of prelabour rupture of membranes (PROM). Patients and Methods: this prospective single-center study involved 80 pregnant women at 32–34 weeks of gestation. Group 1 included 40 pregnant women with PROM and group 2 included 40 pregnant women with threatened preterm labor. Serum levels of presepsin (PSP), leukocyte count, and C-reactive protein (CRP) were measured at admission and after 24 and 48 hours. A somatic, gynecological, and obstetric history was also studied Results: pregnant women with PROM exhibited an aggravated somatic, gynecological, and obstetric history, which could be a prerequisite for purulent septic complications. Elevated PSP levels (≥300 pg/mL) were observed in 23 (57.5%) women in group 1 and 2 (5%) women in group 2. Chorioamnionitis developed in 7 (17.5%) women in group 1 with PSP levels ≥500 pg/mL and two or more clinical signs. Leukocytosis and elevated CRP were detected in 3 (7.5%) and 5 (21.7%) women, respectively. No cases of postpartum endometritis were reported. Mean-while, in group 1, partial abdominal wound dehiscence after C-section was found in 4 of 11 (36.4%) women and partial perineal wound dehiscence was found in 2 of 40 (5%) women. All complications were observed in women with high PSP at admission. No complications were de-tected in group 2. Conclusion: elevated PSP can be considered as a predictor for purulent septic complica-tions in women with PROM. This marker can be used as an additional criterion for revising treatment and choosing term and mode of delivery. PSP level reflects early manifestations of pu-rulent septic complications more quickly than CRP level and leukocyte count. KEYWORDS: prelabour rupture of membranes, preterm birth, chorioamnionitis, markers of inflammation, presepsin, C-reactive protein, strategy FOR CITATION: Kondratyuk D.V., Sulima A.N., Babich T.Yu. Comparative analysis of the monitoring of inflammatory biomarkers in pregnant women with prelabour rupture of membranes. Russian Journal of Woman and Child Health. 2024;7(2):150–154 (in Russ.). DOI: 10.32364/2618-8430-2024-7-2-10.