Краткая история адреномиметиков и улучшенные комбинации в лечении заболеваний верхних дыхательных путей

Abstract

One of the important components in the treatment of inflammatory diseases of the upper respiratory tract is the use of topical adrenomimetics, the irrational use of which leads to the development of local and systemic side effects. To minimize the negative effects, it is necessary to use modern vasoconstrictive drugs that have a complex effect due to the addition of medicines to their composition that improve mucociliary clearance, moisturize the mucous membrane of the nasal cavity and paranasal, regeneration processes. The aim of the work was to study the possibility of effective use of a decongestant with alpha-adrenomimetic activity xylometazoline in combination with sodium hyaluronate. The material for the study was a review of the literature on the use of vasoconstrictors in practical otorhinolaryngology for the period 2003–2023, in domestic specialized publications eLibrary, and scientific databases Scopus, Web of Science, Medline. A brief review of the research methods described by the authors as well as the results of drug therapy was conducted. As a result of the study, it was revealed that in the daily practice of an otorhinolaryngologist local short-acting decongestants are frequently prescribed drugs. They are used during diagnostic procedures, for therapeutic purposes, and, if used irrationally, can cause local and systemic side effects. Conclusion. To a greater extent, side effects are inherent in short-acting drugs; prolonged decongestants should be used, and it is advisable to not exceed the duration of the recommended treatment courses; one of the ways to solve this issue is to add hyaluronic acid to the decongestant.