Abstract
Optimizing the use of antimicrobial agents for acute destructive pancreatitis and pancreonecrosis is an important and far-reaching problem. The lethality, which is often observed in acute destructive pancreatitis and pancreonecrosis in dogs is in most cases caused by toxemia, multiple organ failure and the development of infected pancreonecrosis (complication of sterile pancreonecrosis). Infectious complications, including involvement in the pathological process of surrounding tissues (infected pancreonecrosis, infected cysts, peritoneum phlegmon) are observed in most animals with pancreonecrosis. According to existing veterinary medicine tactics for the canine acute destructive pancreatitis and pancreonecrosis treatment, the main focus is on timely diagnosis of infectious complications, however, recently, the priorities of therapy are shifting towards the prevention of translocations of bacteria. The purpose of our study was to determine the microbial composition of pancreatic effusion in case of infected pancreonecrosis, and to justify the feasibility of using antibiotic prophylaxis taking into account the sensitivity of microorganisms. The detected microorganisms exhibited intermediate resistance to piperacillin in combination with tazobactam, tobramycin and sulfamethoxazole. The highest sensitivity is set to colistin sulfate and ciprofloxacin. Infection of the pancreas and surrounding tissues is due to microorganisms of the KES group, and to a lesser extent Enterobacter sakazakii and Escherichia coli. No cases of mono-infection were reported during the study. The most effective means of early prevention of purulent and septic complications in dogs for pancreonecrosis is colistin sulfate and ciprofloxacin, which is confirmed by a test for the sensitivity of the detected microflora. The microflora isolated from hemorrhagic and serous effusions in dogs with pancreonecrosis resistant to gentamicin, doxycycline, levofloxacin and exhibiting intermediate resistance to piperacillin / tazobactam, tobramycin and sulphanilamide – sulfamethoxide.
Highlights
Optimizing the use of antimicrobial agents for acute destructive pancreatitis and pancreonecrosis is an important and far-reaching problem
The lethality, which is often observed in acute destructive pancreatitis and pancreonecrosis in dogs is in most cases caused by toxemia, multiple organ failure and the development of infected pancreonecrosis
According to existing veterinary medicine tactics for the canine acute destructive pancreatitis and pancreonecrosis treatment, the main focus is on timely diagnosis of infectious complications, recently, the priorities of therapy are shifting towards the prevention of translocations of bacteria
Summary
Infection of the pancreas and surrounding tissues is due to microorganisms of the KES group, and to a lesser extent Enterobacter sakazakii and Escherichia coli. Установлено, что при панкреонекрозе собак инфицирование поджелудочной железы и окружающих тканей чаще всего происходит микроорганизмами KES-группы (Klebsiella-EnterobacterSerratia), второе место по значимости составляет Enterobacter sakazakii, третье - Escherichia coli. Заражение поджелудочной железы и окружающих тканей происходит из-за микроорганизмов группы KES и в меньшей степени Enterobacter sakazakii и Escherichia coli. Встановлено, що за панкреонекрозу собак інфікування підшлункової залози та навколишніх тканин найчастіше відбувається мікроорганізмами KES-групи (Klebsiella-Enterobacter-Serratia), друге місце за значимістю становить Enterobacter sakazakii, третє – Escherichia coli. Згідно існуючих у ветеринарній медицині тактик лікування собак за панкреонекрозу і гострого деструктивного панкреатиту основний акцент зводиться до своєчасної діагностики інфекційних ускладнень, однак, останнім часом пріоритети терапії зміщуються у бік профілактики транслокацій бактерій пробіотиками і максимально ранньої ентеральної годівлі. Метою нашого дослідження було визначення мікробного складу панкреатичного випоту за інфікованого панкреонекрозу та обґрунтування доцільності використання антибіотикопрофілактики із урахуванням чутливості мікроорганізмів
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