Перспективы применения ингибиторов янус-киназ в терапии анкилозирующего спондилита и псориатического артрита

Abstract

The Janus kinase inhibitors are oral targeted synthetic basic anti-inflammatory drugs that exert their influence on the intracellular signaling system, preventing the activation of inflammatory processes. Now, there are a sufficient number of janus kinase inhibitors that have found application not only in rheumatology, but also in other specialties (gastroenterology, dermatology, hematology, oncology and even veterinary medicine). Thanks to janus kinase inhibitors, suppression of the intracellular signaling pathway of several cytokines simultaneously became available, as a result of which it became possible to exert a complex pathogenic effect. This explains the wide range of applications of these drugs in many areas of medicine. In rheumatology, janus kinase inhibitors are finding new and new applications in the treatment of not only rheumatoid arthritis, but also other diseases. This article presents studies on ankylosing spondylitis and psoriatic arthritis, the results of which demonstrate high rates regarding the use of janus kinase inhibitors for the treatment of these diseases.