Функціональний стан нирок після активації аденозинтрифосфатчутливих калієвих каналів при експериментальній гострій гіпоксії

Abstract

In the experiments on non-linear white rats with the model of acute hypoxia we have studied the changes of the functional state of kidneys after a single intraventricular administration of the original fluorine-containing KATP-sensitive potassium channels activator flocalin at the dose of 5 mg/kg on the background of induced water load. It has been shown that under the influence of prohypoxic factors: sodium nitrite (50 mg/kg, subcutaneously) and dinitrophenol (3 mg/kg, intraperitoneal) flocalin activates volume-regulating, ion-regulating and excretory functions of kidneys. Renal effects after activation of KATP-sensitive potassium channels in the rats with histohemic hypoxia were induced by the changes of tubular and predominantly glomerular processes. The increase of glomerular filtration rate, restoration of volatile distal reabsorption of potassium channels, decrease of sodium loss with urine, decrease ofproteinuria after a single administration of flocalin under conditions of acute hypoxia complement the range of protective effects of KATP-sensitive potassium channels activator flocalin.