Ассоциация неалкогольного стеатоза печени с гастроэзофагеальным рефлюксом у больных воспалительными заболеваниями кишечника

Abstract

Background: to date, the question of possible association between non-alcoholic fatty liver disease (NAFLD) and gastroesophageal reflux disease (GERD) is being considered. This association may be due to common risk factors for these two conditions, for example, obesity. However, several study results suggest the role of pro-inflammatory cytokines in the pathogenesis of NAFLD and GERD. Of great interest is the study of these syndromes association in a group of patients with diseases accompanied by a systemic inflammatory process. Aim: study of the association of NAFLD and GERD in a group of patients with inflammatory bowel diseases (IBD) without obesity and other metabolic risk factors. Patients and Methods: the study involved 58 patients with a diagnosis of IBD. The study did not include patients with overweight, obesity and other metabolic risk factors. The presence of GERD was assessed based on survey data, the GERD-Q questionnaire and the results of an endoscopy. Results and Discussion: the presence of GERD was associated with the presence of NAFLD in the studied group of patients (odds ratio (OR)=5.17; 95% confidence interval (CI) 1.46–18.28). There were no statistically significant differences in body mass index (BMI) between the groups of patients with NAFLD and without NAFLD (21.05 kg/m2 vs. 20.04 kg/m2, respectively, p=0.419). There was no statistically significant association of NAFLD with the use of systemic glucocorticosteroids in the anamnesis (OR=1.11; 95% CI 0.3–4.05), the presence of episodes of weight loss in the anamnesis (OR=0.48; 95% CI 0.11–2.11). Conclusion: in patients with IBD, NAFLD is associated with the presence of GERD, regardless of BMI, the presence of carbohydrate metabolism disorders, as well as a history of weight loss episodes. KEYWORDS: gastroesophageal reflux disease, fatty liver disease, inflammatory bowel diseases. FOR CITATION: Krasner Ya.A., Osipenko M.F., Bikbulatova E.A., Kholin S.I. Association of non-alcoholic fatty liver disease with gastroesophageal reflux disease in patients with inflammatory bowel diseases. Russian Medical Inquiry. 2021;5(6):373–376 (in Russ.). DOI: 10.32364/2587-6821-2021-5-6-373-376.