Abstract
Characteristic of chromosomal abnormalities in bone marrow cells among 123 children with acute myeloid leukemia were presented according five aging groups: I – up to 2 years, II – 2–5 years, III – 5–10 years, IV – 10–15 years, V – 15–18 years. Normal karyotype wasn’t found in group up to 2 years and in low presented in another groups (5,9–10,3 %). The highest frequency of chromosomal abnormality evolution in group up to 2 years was established (69,2 %). The highest frequency of hyperdiploidy (47–50 chromosomes) in group 15–18 years (31 %) was found. More often near-tetraploidy and pseudodiploidy clones were met in group 2–5 years (47 % and 58,8 %, respectively). Between structural types in all groups were predominated translocations and deletions. In group up to 2 years was prevalented translocations (61,5 %), 2–18 years – deletions (64,7; 34,5; 45,7 and 41,4 % respectively). In group up to 2 years more often were met abnormalities chromosomes (Chr) 9, 11, 16 (in 30,8 %), 2–5 years – Chr 16, 21 (in 29,4 %), 5–10 years – Chr 11 (24,1 %), 8, 15, 17 (in 17,2 %), 10–15 years – Chr 16 (40 %) and 15–18 years – Chr 8, 9, 15, 17 (in 17,2 %).
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