Передчасний розрив плодових оболонок: нові генетичні чинники та можливий патогенез їхньої реалізації

Abstract

The results of the study of gene polymorphism of glutathione-S-transferase in pregnant women with premature rupture of membranes are considered in the article. The objective: to find the pathogenetic factors of premature rupture of membranes and improve the algorithm of reference of patients with this complication in preterm pregnancy. Patients and methods. The study involved 68 pregnant women with premature rupture of membranes at term pregnancy and 37 women in the active phase of the first period of preterm birth with intact membranes. Gene polymorphism of glutathione-S-transferase, and the activity of key indicators of lipid peroxidation and antioxidant enzyme system were identified in all patients. Results. The dominance among pregnant women with premature rupture of membranes carriers homozygous form of one or more of this group of genes is demonstrated. The observed intensity of lipid peroxidation identified as a pathogenic factor in prenatal rupture of amniotic membranes. The dependence of the high content of lipid peroxidation products of phase II detoxification gene polymorphism is demonstrated by high values of the Spirman coefficient – from 0.71 to 0.74. Conclusion. The phase II detoxification genetic polymorphism is clearly associated with the accumulation of secondary products of oxidation, which may indicate metabolic disorders on the edge of the cell membrane, which actually is a factor in premature rupture of membranes. These features contribute to the pathogenesis of inflammation and generalization. Кey words: рreterm membrane rupture, glutation-S-transferase, lipid peroxidation.