Abstract
This work published and original data about the effects of various stressful stimuli on neuroendocrine and immune system development in animals and humans, with particular focus on effects of maternal infection, inducing inflammation, on developing fetus. Inflammatory processes may modify physiological levels of regulatory factors and hence disrupt developmental mechanisms. The central nervous system is particularly affected by inflammatory products during critical periods of ontogenesis. It leads in prospect to an increase of risk of different psychoneurological diseases, such as autism, Alzheimer’s disease, Parkinson’s disease, schizophrenia and depression, in the offspring. Inflammation-induced disorders of reproductive axis can lead to suppressed reproductive ability and infertility. Epigenetic mechanisms of development are highly sensitive to various regulatory factors, that opens up opportunities for disorder correction. Attempts to prevent the after-effects of prenatal inflammation are made over recent years. The approaches aimed at timely detection and correction of the perinatal disorders open a prospect of health maintenance in adult offspring.
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