Abstract
Diseases of the gastrointestinal tract (GIT) are one of the reasons for the development of iron deficiency anemia (IDA). The presence of gastroenterological pathology often leads to the refracterity of anemia to standard therapy, which necessitates timely diagnosis and adequate correction of background disease. A rare variant of anemia refractory to ferrotherapy is iron-refractory IDA (IRIDA), whose genesis contains an iron exchange disorder caused by a mutation in the TMPRSS6 gene. The article discusses the differential diagnostic spectrum of GIT diseases as potential causes of anemia, examines the pathogenetic mechanisms of IRIDA in a clinical trial, which required the elimination of a genetically deterministic iron exchange disorder at the diagnostic stage.
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