Показатели тестостерона в сыворотке крови и гемодинамики тестикул до и после инфицирования SARS-COV-2 (пилотное исследование)

Abstract

INTRODUCTION: The current epidemiological situation dictates a detailed study of the effect of a new coronavirus infection (SARS-CoV-2) on various anatomical, histological, physiological and biochemical parameters of the human body, which has become an integral part of many medical research, including urology, andrology, endocrinology. OBJECTIVE: To study serum testosterone levels and testicular hemodynamics before and after infection with SARS-CoV-2. MATERIALS AND METHODS: 20 patients were examined, before and after suffering SARS-CoV-2 infection (who fell ill at the beginning of 2020). Average age 37.8 years (min=27, max=50). The level of total testosterone (s) in the blood serum and hemodynamic parameters of the testicles (maximum and minimum blood flow velocity and resistance index) were studied. RESULTS: When studying the level of s 3 months after the transferred SARS-CoV-2, its decrease from the initial value was noted (r=0.47;p=0.35), and after 6 months (r=0.98;p<0.007) there was no recovery of the target level of Ts before infection with SARS-CoV-2. Regarding the hemodynamics of the testicles, there was also a decrease in Vmax and Vmin, and an increase in RI, which indicates a deterioration in the blood flow of the testicles (p<0.001). CONCLUSION: SARS-CoV-2 affects the level of Ts in the blood serum and the parameters of the hemodynamics of the testicles. The extent to which SARS-CoV-2 affects patient performance depends largely on the severity of the disease and to a lesser extent on baseline performance.