Abstract
(1) In a number of systematic experiments the biological conditions were determined in detail of the formation of pyrogenic substances in the reaction of hypersensitive cells with the specific antigenin vitro: the role of the quantitative relationship of cells and antigen, of temperature and incubation period, of cell viability, etc. A part of the experiments was performed with131I labelled antigen. (2) It has been demonstrated that pyrogenic substances are also formed on mixing cell-free extracts of hypersensitive cells with specific antigen, and the conditions of this reaction are defined. (3) In various experimental conditions a significant conformity was found between the formation of pyrogenic substances inin vitro experiments and the possibility of passive transfer of systemic delayed type hypersensitivity. (4) After testing pyrogenic substances and after provoking the systemic hypersensitivity reaction in passively sensitized animals, an increased susceptibility to the pyrogenic effect of other substances was observed. (5) The experimental results presented are discussed from the point of view of our previous papers and with regard to contemporary knowledge on the mechanism and significance of delayed type hypersensitivity.
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