Abstract
Under fusemide-induced hypomagnesemia in animals, the hydroxy form of magnesium orotate shows a higher rate of compensation for magnesium deficiency in the blood compared to the oxo form. Furosemide load is accompanied not only by hypomagnesia, but also by the development diselementosis of the body. Changes in elemental status are different depending on the organ. The amount of magnesium in the furosemide load decreases in serum, does not change in the heart, rises in the spleen and thymus. The injection of the hydroxy form of magnesium orotate levels the ratio of micro- and macronutrients in blood plasma and organ tissues. Magnesium deficiency is accompanied by signs of immuno-inflammatory reaction, leuko- and lymphocytosis, eosinophilia, a decrease in the number of erythrocytes and a decrease in the level of hemoglobin. An earlier and complete restoration of cytological parameters is noted in the group of animals with the introduction of hydroxy form of magnesium orotate.
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