Гостре ураження нирок у доношених новонароджених після асфіксії та роль поліморфізму АСЕ, AGT2R1, eNOS генів у його розвитку

Abstract

Background. Acute kidney injury (AKI) is a fairly common pathology among newborns who had asphyxia at birth. Objective. To analyze the incidence of AKI in neonates with asphyxia, and study the impact of functional polymorphisms of genes ACE, AGT2R1, eNOS in its development. Methods. A prospective cohort study was conducted, which included 72 newborns with Apgar scores at birth <6 points. The criterion for determining AKI became creatinine level above 130 mg/dL after 48 hours of life. In these cohorts of infants I/D polymorphism of ACE gene, A/C polymorphism of AGT2R1gene and a/b polymorphism of eNOS gene were defined. Statistical processing of the results took place using simple and multiple logistic regression analysis. Results. In 20 (27.8%) of newborns with asphyxia creatinine level was above 130 mg/dL, only 6.94% of the infants had oliguria. With the development of AKI at multiple logistic regression analysis AA genotype of AGT2R1 gene (OR 0.21), Apgar score at 5 minutes of life (0.30) and meсonium aspiration (OR 6.02) were significantly associated. Conclusions. AA genotype of AGT2R1 gene significantly reduces the chances of the child with asphyxia to have acute kidney injury. Key words: neonates, asphyxia, acute kidney injury, ACE, AGT2R1, eNOS, gene polymorphism.