Комплексний підхід до лікування раннього токсикозу у вагітних після застосування допоміжних репродуктивних технологій

Abstract

Obstetricians-gynecologists do not always pay sufficient attention to nausea and vomiting of pregnancy (NVP), sometimes its severity is underestimated and adequate treatment is not prescribed. The objective: to investigate the efficacy and safety of the complex therapy of NVP in pregnant women after ART, including a preparation of ginger extract with pyridoxine and psychotherapy. Materials and methods. Sixty pregnant women were examined after applying VRT, with mild manifestations of NVP. The main group consisted of 30 women, with Emegest (ginger and pyridoxine extract) and psychotherapy used in NVP therapy, and a comparison group of 30 women who only adhered to recommendations on changes in diet and life. The presence of the syndrome of autonomic dysfunction was established using the A.M.Veyn questionnaire. For self-assessment of the level of reactive and personal anxiety, testing was carried out according to the method of Ch.D. Spilberger, Yu.L. Khanin. The quality of life was assessed using the SF-36 questionnaire. Results. The use of recommended NVP therapy in pregnant women after ART makes it possible to improve the condition of women already for 2–3 days, and in 2 weeks of treatment it is essential to reduce or even eliminate the symptoms of NVP. Complex therapy reduces the severity of the syndrome of autonomic dysfunction and the level of personal and situational anxiety, which, against the background of improving the overall condition, positively affects the quality of life. The applied therapy had no side effects or complications, positively influenced the further course of pregnancy and the condition of the fetus and the newborn, in particular, the frequency of preeclampsia is decreased by half and the birth asphyxia by 1.5. Conclusion. The safety and efficacy of Emegest in the complex therapy of nausea and vomiting of pregnancy allows us to recommend its use in pregnant women after ART. Key words: nausea and vomiting of pregnancy, Emegest, auxiliary reproductive technologies, psychotherapy.