Abstract
Biochemical characteristics of kidneys, pe- ripheral blood and bone marrow of rats in model of tumor growth under introduction of cisplatin and cis-tetrachlorodi-μ-isobutyratodirhenium(III), cis-Re2(i-C3H7COO)2Cl4 (I) have been investigated. It was shown that introduction of I alone and together with cisplatin led to decrease of biochemical markers of oxidation of lipids and proteins in tissue homogenates of the kidneys, change of enzyme activity in the urea and tissue homogenates of the kidneys, by a decrease of filtration function of kidneys. Introduction of nanoliposomal forms of the rhenium cluster compound led to a practically normal morphological picture of bone marrow and increase of the RBC (by 60%) with normalization of hematocrit counts, and decrease of quantities of destructed RBC (3.2 times) in comparison with the tumor-bearing animals. A tentative scheme of influence of cluster rhenium compound on erythropoiesis through regulation of synthesis of erythropoietin in kidneys has been proposed.
Highlights
The biomedical application of pristine С60 fullerene requires a comprehensive study of possible displays of its toxic effect in the whole organism, as well as in the isolated cells
It is assumed that basic mechanisms of its toxic effect are lipid peroxidation, oxidative stress dissemination and genotoxicity [13]
C60 fullerene did not increase the level of DNA strand breaks, but significantly increased the level of FPG sensitive sites/oxidized purines determined by a comet assay in lung epithelial cell line [10]
Summary
The biomedical application of pristine С60 fullerene requires a comprehensive study of possible displays of its toxic effect in the whole organism, as well as in the isolated cells. This allotropic form of nanocarbon possesses a unique structure, physical and chemical properties and biological activity in vitro and in vivo [1,2,3]. Numerous studies with using different cell types revealed that C60 fullerenes possess genotoxic activity. The genotoxicity of C60 fullerene in vitro and in vivo strongly depends on the size of its aggregates, dose administration, type of cells and duration of exposure. Some special biological effects of pristine С60 fullerenes, such as anticancer activity, were detected [22, 23]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
