Abstract
Thymuses investigated biopsies from children 1 year of age (n = 77) in patients with congenital heart defects of varying difficulty. Immunohistochemistry verified the accumulation of keratin in epitelioretkulotsitah (PanCK), thymopoiesis assessed by expression of CD3 + . Serum levels thymuline investigated. The degree of complexity of heart disease determines the morphological changes in the body, under which a large complex tissue reactions. During the first year of life (1, 6, 11 months.) In the thymus was observed decrease in the expression of keratins, accompanied by a breach of the architectonics of epithelial stroma, which affect the level of thymopoiesis, lowering it. Studies have shown that immunomorfologicheskie features correlated with the degree of complexity of a heart defect and the level of hormones in the peripheral blood, which was significantly lower than in healthy children.
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