Abstract
Flavors “Caramel” induced in root meristem cells of onion Allium cepa L. single and paired fragments of chromosome and dicentric chromosomes, which are the result of chromosomal aberrations such as deletions and translocations. It was found induction of dominant lethal mutations and unfertilized eggs by different concentration of flavors in Drosophila melanogaster test. As well as under flavors influence we have shown the induction of a wide range of chromosome aberrations in metaphase bone marrow cells of white mice Mus musculus L., which included not only chromosomes but also genomic mutations. This could be evidence of spindle apparatus disruption and chromosomes nondisjunction as an influence of mutagenic agents, which may include a flavoring component themselves as well as their metabolites appearing in the biotransformation in mammal’s organism. We observed a partial decrease of aberrant metaphases and dominant lethal mutations after vitamin A and C application.
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