Abstract
Background. Hepatitis B virus (HBV) infection remains a global public health problem. Objective – to analyze the prevalence of viral coinfections with human immunodefciency virus (HIV), hepatitis C virus (HCV), hepatitis delta virus (HDV), TT-viruses and SENV in patients with chronic hepatitis B (CHB) and to assess their influence on liver disease severity. Material and methods. The observational cross-sectional study included 287 patients with chronic hepatitis B virus (HBV) – those with monoinfection and coinfected with HIV, HCV, HDV. Routine hematological and biochemical tests were performed, serum HBV DNA level as well as liver fbrosis stage were measured. Blood samples from 62 patients for Torque teno virus (TTV), Torque teno mini virus, Torque teno midi virus, SENV (D and H genotypes) DNAs were examined by polymerase chain reaction. Results. Among patients with CHB the prevalence of coinfection HBV + HIV is 6.6%, HBV + HCV – 6.3%, HBV + HDV – 3.8% and HBV + HDV + HCV – 1.7%. CHB patients coinfected with HIV, HCV, HDV had more pronounced biochemical differences and higher proportion of liver cirrhosis vs. HBV-monoinfected ones. The detection rate of TT viruses and their various combinations in patients with CHB is 91.9%, SENV – 66.1%. Conclusion. Coinfection with HIV, HCV, HDV in CHB patients is associated with more severe forms of chronic liver disease as compared to HBV-monoinfection. TT viruses and SENV are widespread and don’t affect the severity of liver disease in patients with CHB.
Highlights
Hepatitis B virus (HBV) infection remains a global public health problem
Blood samples from 62 patients for Torque teno virus (TTV), Torque teno mini virus, Torque teno midi virus, SENV (D and H genotypes) DNAs were examined by polymerase chain reaction
chronic hepatitis B (CHB) patients coinfected with human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis delta virus (HDV) had more pronounced biochemical differences and higher proportion of liver cirrhosis vs. HBV-monoinfected ones
Summary
Цель исследования – проанализировать распространенность сочетанных вирусных инфекций: вирус иммунодефицита человека (ВИЧ), вирус гепатита С (ВГС), вирус гепатита дельта (ВГD), TTV и SENV у пациентов с хроническим гепатитом В (ХГВ), оценить их влияние на тяжесть заболевания печени. В обсервационное поперечное исследование включены 287 пациентов с ХГВ (включая моно-инфекцию, а также ко-инфицированных ВИЧ, ВГС, ВГD). У пациентов с ХГВ и коинфекцией ВИЧ, ВГС, ВГD более выражены биохимические синдромы поражения печени и чаще развивается цирроз печени, чем при ВГВ-моноинфекции. Коинфекция ВИЧ, ВГС, ВГD при ХГВ характеризуется более тяжелым течением заболевания печени, чем при ВГВ-моноинфекции. Вирусы группы ТТ и SENV широко распространены и не влияют на тяжесть заболевания печени у пациентов с ХГВ. VIRAL COINFECTIONS IN PATIENTS WITH CHRONIC HEPATITIS B: THEIR PREVALENCE AND CLINICAL SIGNIFICANCE. V. Osipkina 1Gomel Regional Infectious Clinical Hospital, Gomel, the Republic of Belarus
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