Морфологическое состояние гепатоцитов крыс при остром эмоционально-болевом стрессе на фоне применения селанка

Abstract

We studied the morphological state of liver tissue and morphometrical parameters of hepatocytes in Wistar male rats subjected to acute foot-shock stress and Selank influence on liver condition. The peptide was administered by intraperitoneal injections in doses 100, 300 and 1,000 µg/kg 15 min before stress exposure. We revealed that acute foot-shock stress resulted in developing mild hepatocytic degeneration which was more pronounced in centrilobular regions, inflammatory infiltration which was more developed in peripheral parts of liver lobules, growth of the mean areas of hepatocyte, nucleus, and cytoplasm without changes of NCR. Selank showed an ameliorative effect on stress-induced alterations. The 100 µg/kg peptide administration influenced the dystrophic changes greater, 300 µg/kg peptide administration had a greater impact on the inflammatory infiltration, 1,000 µg/kg Selank application showed an average effect on the parameters above-mentioned. The peptide administration didn’t influence the mean area of hepatocyte; however it led to further growth of the mean area of nucleus in doses 100 and 1,000 µg/kg.