Стан системи прооксидантноантиоксидантної рівноваги в процесі комплексної терапії у хворих на вогнищеву склеродермію

Abstract

Introduction. The development of oxidative stress in focal scleroderma is the basis for the use of antioxidant therapy in the treatment of this disease, in connection with which drugs of natural antioxidants are of interest. The objective was to study the effect of complex treatment on the level of oxidative stress of proteins and lipids, the state of the antioxidant defense system in focal scleroderma. Materials and research methods. The study included 78 patients with focal scleroderma. In the comparison group (n=38) treatment was prescribed according to the recommendations. In the main group (n=40) to the basic therapy was added tivortin, eliminal gel, ultraphonophoresis with longidase. The contents of dinitrophenylhydrazones of neutral (E370) and basic character (E430), malonic dialdehyde (MDA), hydroperoxides (HP), reduced glutathione (GR), superoxide dimutase (SOD), catalase (CT), glutathionereductase (GR) were analyzed. Results. It was found that the absolute effectiveness of complex therapy in reducing the level of dinitrophenylhydrazones of neutral and basic nature exceeds the baseline by 27.0 and 26.0% (p<0.05). The therapeutic benefit of the inclusion of antioxidants in complex therapy to reduce the level of diene conjugates was 33.0% (p<0.05), the content of HP – 22.0% (p<0.05), MDA – 41.0% (p<0,05). It was proven the reliable therapeutic efficacy of complex treatment to increase the intensity of antioxidant enzymes, which was 28.0% relative to the level of SOD (p<0.05), 26.0% relative to the content of CT (p<0.05), 42.0% – according to the SOD/CT index (p<0.05), as well as 22.0% to increase the activity of GR (p<0.05). Conclusions. Comprehensive treatment of focal scleroderma, with the addition of drugs that have endothelioprotective, antihypoxic and antioxidant effects, reduce the production of free radicals and restore the activity of enzymes of antioxidant protection is highly effective and pathogenetically justified