Влияние иммобилизованной формы пробиотического препарата «Экофлор» на показатели неспецифического гуморального иммунитета осетровых рыб

Abstract

Currently, due to the intensive development of aquaculture, interest in the study of the immune system and im-mune response in fish has increased. When growing fish in aquaculture, the conditions of their maintenance should contribute to maintaining the optimal activity of innate immunity. It has been established that the immunity of fish is more dependent on external influences, and environmental conditions are active regulators of fish immunoreactivity. Currently, various probiotic preparations with the ability to correct microbiological and immune parameters due to the action of symbiotic microorgasms have been widely used in aquaculture to increase and regulate the immune homeostasis of fish. Information is presented on the conduct of experimental studies to assess the effect of the probiotic drug “Ecoflor”, immobilized on enterosorbent, on the level of bactericidal activity of blood serum, the number of immunodeficient individuals, the content of nonspecific immune complexes in blood serum and immunocompetent organs, as well as on the level of C-reactive protein of sterlet yearlings (Acipenser ruthenus Linnaeus, 1758). It is noted that the use of a probiotic drug in an experi-mental dosage of 6 g/kg of compound feed has an effect on the indicators of nonspecific humoral immunity. Thus, sterlet grown on compound feeds with the specified rate of drug administration is characterized by an increased level of bactericidal activity of blood serum – 98% and the absence of immunodeficiency – 0%. In addition, this dosage helps to reduce the concentration of nonspecific immune complexes in the blood serum to 2.25 ± 1.65 and immunocompetent organs of sterlet yearlings: in the liver and spleen to 0.06 ± 0.02 and 0.30 ± 0.30, respectively. The results of the analysis of the level of C-reactive protein indicate that this drug does not cause inflammatory reactions in the body of fish.