СРАВНИТЕЛЬНЫЙ АНАЛИЗ СОСТОЯНИЯ ИММУННОЙ СИСТЕМЫ ДЕТЕЙ И ПОДРОСТКОВ С РАЗНЫМ СОЦИАЛЬНО-НЕВРОЛОГИЧЕСКИМ СТАТУСОМ

Abstract

The present paper provides comparative analysis of the immune parameters in children and teenagers with different socio-neurological status, residents of Simferopol. These data were analyzed in children under 4 years old and teenagers 7-15 years old from families and orphanage. Immune parameters were determined by immunofluorescence assays (IFA) and enzyme immunoassay (ELISA) and intergroup differences were evaluated by Student’s test. Activation of the cellular immunity was observed in younger children – social orphans with neurological diseases and with no significant differences in teenagers except of the total number of leukocytes. The number of children with normal values of the parameters of cellular immunity was 50% in social orphan children and those with neurological disorders in both age groups, while among children and teenagers with not known diseases it was 100% and 65%, respectively. In humoral immunity a decreased number of B-lymphocytes in both groups and statistically significant differences in 0-lymphocytes content and immunoglobulins were observed, increasing with age and indicating a greater tendency for allergic disorders in family children and greater deficit of local immunity in children and teenagers – social orphans and with neurological disorders. The total number of children with normal parameters of humoral immunity was 57% in both younger groups, 14% had increased parameters, and 29% – less than normal. In both teenagers’ groups the number of children with deviations of parameters from the normal values in humoral immunity was the same: within the norm – 43%, above – 14%, below the norm – in 43%. Revealed changes of the immunity are similar to those observed in children from large cities and industrial agglomerations, but specific changes were detected in children with compromised social and neurological status.