Abstract
Goal of the study : to evaluate the test with tuberculous recombinant allergen (TRA) in the patients with effective treatment course due to tuberculosis, to investigate the impact of clinical, epidemiological and social factors on persistence of active tuberculosis. Materials and methods . Patients were divided into 2 groups basing on time period after completion of the main treatment course. Group I – 32 patients (up to 6 months), group II – 63 patients (more than 6 months). Results of the study . Results of TRA tests in Group I remained positive in 34.4% of patients and in Group II - 23.8%. The average size of the induration in Group I made 10 mm(95% CI 6.5-13.3), in Group II – 13 mm (95% CI 8.4-19.7) Patients from Group I had positive results of TRA test more often in case of initial infiltrate form of pulmonary tuberculosis and bacillary excretion. In patients from Group II the positive TRA results correlated with presence of concurrent conditions and exposure to a tuberculosis case in the past. Positive results were confidently more often observed in lonely patients in both groups. TRA test can be a valuable tool to evaluate the risk of tuberculosis relapse after completion of the main treatment course.
Highlights
Results of tuberculous recombinant allergen (TRA) tests in Group I remained positive in 34.4% of patients and in Group II - 23.8%
In patients from Group II the positive TRA results correlated with presence of concurrent conditions and exposure to a tuberculosis case in the past
TRA test can be a valuable tool to evaluate the risk of tuberculosis relapse after completion of the main treatment course
Summary
На базе ПТД No 5 обследовано 95 пациентов с впервые выявленным туберкулезом легких на разных этапах наблюдения после завершения эффективного ОКЛ. До начала ОКЛ у них была положительная кожная проба с АТР Среди них: 67 (70,4%) мужчин и 28 (29,5%) женщин в возрасте от 18 до 69 лет (медиана возраста 41,5 года, 95%-ный ДИ 35,5-44,9). Все па циенты были разделены на две группы: I группа 32 пациента со сроком после окончания ОКЛ до 6 мес. (состоящие в I группе диспансерного учета), средний срок окончания ОКЛ составил 3,8 мес. (клинически излеченные лица, состоящие в III группе диспансерного уче та), средний срок после окончания ОКЛ 14 мес. Какие признаки влияют на сохранение положительного результата пробы с АТР после успешного ОКЛ, проанализировали данные об исходной клинической форме, о наличии деструкций, бактериовыделения и лекарственной устойчивости МБТ, токсических побочных реакций на препараты сопутствующих заболеваний. Применяли методы описательной статистики с определением среднего значения выборки, вычислением 95%-ного довери тельного интервала, определением достоверности получаемых результатов
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