Abstract
The influence of indometacine (7 x 10(-8)M) on the tonic contractile activity of the isolated rat portal vein (PV) under the action of adrenaline (1 x 10(-5)M) and noradrenaline (5 x 10(-6)M) was studied. Indometacine decreased the amplitude of noradrenaline-induced tonic constriction of PV with intact endothelium and produced no effect on constriction of vessels with denuded endothelial layer. The results suggest that these reactions are mediated by endothelial prostanoids. Inhibition of adrenaline-induced constriction of PV preparations with intact and denuded endothelium suggests that the contractile reactions are mediated by prostanoides derived from both endothelial and smooth muscle cells.
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