ПРЕДИКТОРЫ ТЕРАПЕВТИЧЕСКОГО ОТВЕТА И ДЛИТЕЛЬНОСТИ ГОСПИТАЛИЗАЦИИ У ПАЦИЕНТОВ С ШИЗОФРЕНИЕЙ В ПРОЦЕССЕ ФАРМАКОТЕРАПИИ

Abstract

Topicality. Search for scientifically based criteria for symptomatic remission and outcomes in schizophrenia is an urgent problem in modern psychiatry. Aim. To determine predictors of therapeutic response and duration of hospitalization during the course of psychopharmacotherapy in patients with schizophrenia. Material and methods. Clinical and metric examination using scales for assessing severity of positive (SAPS, PSYRATS, BABS) and negative (SANS, NSA-5) symptoms was performed in 157 patients with a diagnosis of schizophrenia twice: on admission to hospital and after the course of psychopharmacotherapy. The model for predicting therapeutic response was built using logistic regression, the model for predicting duration of hospitalization was built using linear regression using metrically justified criteria for achieving a significantly low level of severity of positive and negative symptoms as criteria for a significant therapeutic response. Results. The predictors were determined that increase and decrease likelihood of therapeutic response for scales for assessing positive and negative symptoms in patients with schizophrenia during the course of psychopharmacotherapy. Conclusions. Therapeutic response prediction models for scales for assessing the severity of positive symptoms and scales for the severity of negative symptoms are of good quality and high diagnostic value.