Види клітинної загибелі, що реалізуються через вплив активних форм кисню і пошкодження ДНК

Abstract

The purpose of the review was to find and analyze the literature on such types of cell death, which are realized due to DNA damage, namely, mitotic catastrophe; anoikis; pyroptosis; parthanatos and due to the influence of active forms of oxygen, namely mitoptosis; lysosome-dependent cell death; necrosis associated with increased mitochondrial permeability; necroptosis; netosis; ferroptosis. Apoptosis and autophagy, which are realized both due to the influence of reactive oxygen species and DNA damage, are considered separately.Cell death plays an important role in development, tissue homeostasis, inflammation, immunity, and many pathophysiological conditions. On the one hand, it becomes an etiological determinant in diseases associated with the irreversible loss of postmitotic tissues (for example, myocardial infarction, neurodegeneration). On the other hand, defects in the signaling cascades that trigger cell death are associated with pathologies characterized by uncontrolled expansion or accumulation of cells (eg, some autoimmune diseases, cancer). Therefore, cell death can be defined as a promising therapeutic target.