Дисліпідемія та репродуктивні розлади у самців щурів внаслідок тривалого споживання гідрогенізованої пальмової олії

Abstract

The paper focuses on the problem of unbalanced nutrition. The effects of hydrogenated palm oil (solid form) consumption at a dose of 3 g / kg body weight, which exceeded the daily norm by 1,5 times, for 75 days in adult male rats have been experimentally shown. The simulated experimental conditions led to the development of dyslipidemia in the serum and the liver (hypertriglyceridemia, hypercholesterolemia). Signs of androgen deficiency were also found: the content of total and free testosterone in the serum was significantly less than the physiological norm. Also, defects in spermatogenesis were recorded in the experimental animals: total gametes concentration and proportion of morphologically normal gametes decreased, the pathological forms increased. Disorders of androgen-synthetic and spermatogenic functions in the testes were accompanied by histological changes. In testicular tissues, structural rearrangements of a number of seminal tubules have been observed, possibly due to an increase in inactive Leydig cell forms. A decrease in the index of spermatogenesis was found, this reflects the number of generations of spermatogenic cells in the wall of the seminal tubules. An increased number of tortuous seminal tubules with exfoliated germ cells in the lumen have been reported. The reason may be the loss of communication between the germ cells and the supporting Sertoli cells. When the link between the germ cell and the supporting cells is lost, the effects of testosterone are impossible, which leads to a violation of spermatogenesis.