Нейро-вегетативный статус и суточный профиль артериального давления у пациентов с артериальной гипертензией

Abstract

The aim of research is study peculiar properties of vegetative status and 24 hours´ arterial pressure profile in inefficient antihypertensive therapy patients. It was examined 180 patients in age from 42 to 65 with diagnosis I-III degree of arterial hypertension on classification RSOC; volunteers without arterial hypertension and sporadic rise of pressure has been integrated into research (n=36). Clinical and biochemical monitoring realized to the whole of examines in accordance with standards on diagnostic of arterial hypertension. 24 hours´ profile arterial pressure will be done in conformity with guideline national joint committee on cure of arterial hypertension JNK VI, WHO/ISH. Determination predominant autonomic balance carried out from system for integrated vegetative status, by its results patients were divided into subgroups. Then the patients were separated into subgroups by predominant autonomic balance with a glance degree and phase of arterial hypertension; modification key indicator of 24 hours´ arterial pressure profile in subgroups was investigated. It has been found experimentally that type of predominant autonomic balance varies with the phase, by not with degree of arterial hypertension. Inefficient antihypertensive therapy patients have more high frequency and variability of cardiac rhythm, which combine with insufficient degree decrease of cardiac rhythm at night; more high value of systolic, diastolic, sphygmic and medium pressure comparison with control group. Complex hemodynamic rates (DP, maxIMP) and also bodymass index in inefficient antihypertensive therapy patients exceed the same in efficient treatment cluster.