Abstract
Psoralens are medicinal photosensitizing furocoumarins which are used in photochemotherapy and photoimmunotherapy of dermatoses. Psoralen photooxidation products may be involved in therapeutic effects, but the possible mechanisms of their action remain unclear. The study was aimed to assess the prospective pharmacological effects and mechanisms of activity for six previously identified ortho–hydroxyformyl-containing psoralen photooxidation products and their cycloadducts with aminothiols, as well as for structurally similar compounds (furocoumaric acid and tucaresol). Chemoinformatic analysis of the prospective pharmacological effects and mechanisms of action of these compounds was performed using the PASS and PharmaExpert software. The predicted pharmacological effects partially confirmed by previous studies highlight the possible involvement of psoralen photooxidation products in the effects of PUVA therapy or photopheresis during the course of dermatoses and proliferative disorders treatment. A broad spectrum of pharmacological effects found for furocoumaric acid and cycloadducts of coumarinic and benzofuranic photoproducts of psoralen with cysteine and homocysteine appoints new directions of research relating to therapeutic use of psoralens.
Highlights
Psoralens are medicinal photosensitizing furocoumarins which are used in photochemotherapy and photoimmunotherapy of dermatoses
– 0.899/0.004 0.741/0.019 0.538/0.020 0.807/0.004 0.701/0.010 0.791/0.005 0.620/0.016 0.537/0.014 0.513/0.014 0.512/0.015 0.506/0.018 presence of oxygen during irradiation of psoralen solution [10]. That makes it possible to limit the search by previously characterized psoralen photooxidation products (POP products)
Photolysis products of furocoumarins and the pathways leading to their formation are exhaustively reviewed [13]
Summary
Psoralens are medicinal photosensitizing furocoumarins which are used in photochemotherapy and photoimmunotherapy of dermatoses. Psoralen photooxidation products may be involved in therapeutic effects, but the possible mechanisms of their action remain unclear. The study was aimed to assess the prospective pharmacological effects and mechanisms of activity for six previously identified ortho–hydroxyformyl-containing psoralen photooxidation products and their cycloadducts with aminothiols, as well as for structurally similar compounds (furocoumaric acid and tucaresol). The predicted pharmacological effects partially confirmed by previous studies highlight the possible involvement of psoralen photooxidation products in the effects of PUVA therapy or photopheresis during the course of dermatoses and proliferative disorders treatment. Предсказанные фармакологические эффекты, частично подтверждаемые результатами ранее проведенных исследований, свидетельствуют о возможном участии продуктов фотоокисления псораленов в реализации эффектов PUVA-терапии или фотофереза при лечении ряда дерматозов и пролиферативных патологий. А. Лагунин — дизайн исследования, анализ литературы, подготовка текста рукописи; М. В. Малахов — дизайн исследования, анализ литературы, интерпретация данных, подготовка и окончательная редакция текста рукописи
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