Abstract
Objective: To study cognitive changes in patients with akinetic-rigid and tremor-dominant Parkinson’s disease (PD). Methods: From January to May 2019 were examined and responded 32 patients with akinetic-rigid (n=15; 46.9%) and tremor-dominant (n=17; 53.1%) PD. The average age of the patients was 66.5±3.7 years. All patients of PD before and after receiving appropriate therapy were responded using the MMSE (Mini-Mental State Examination) scale to detect the possible cognitive dysfunctions. The study of cognitive functions in patients was conducted before the start of therapy, as well as 3 months after treatment. Results: At the admission, cognitive disorders were more significant in akinetic-rigid PD than in a tremor-dominant PD. After 3 months of appropriate therapy, cognitive dysfunction rates in patients with akinetic-rigid PD improved significantly (p<0.001) in compare to tremor-dominant PD (p<0.05). Conclusions: Using the MMSE scale helps to detect and determine the severity of cognitive changes in a timely manner and the risk of further development of dementia in patients with PD, that allows to start corrective activities in time. Timely detection and appropriate approach to the treatment of the underlying disease and the correction of cognitive impairment significantly improves the quality of life of patients themselves, contributes reducing economic costs. Keywords: Parkinson’s disease, cognitive disorders, akinetic-rigid and tremor-dominant Parkinson’s disease, MMSE scale.
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