Abstract
Objective: to study typical manifestations of newly diagnosed pulmonary TB in patients with viral hepatitis (VH) co-infection. Materials and methods. The cohort cross-sectional study included 35 patients with newly diagnosed pulmonary TB; out of them 15 patients had pulmonary TB and hepatitis virus C or B co-infection (group 1) and 20 patients had pulmonary TB alone (group 2). The study was carried out in 2019–2023. Results. Among patients with TB/VH co-infection men aged 50–59 and women aged 60–69 years either with unhealthy habits (including alcohol and substance abuse), or ex-prisoners, or those burdened with comorbidities (gastrointestinal diseases, cardiovascular diseases, type 2 diabetes mellitus) prevailed. In these patients we commonly observed tuberculomas, small destructive changes, and preserved susceptibility to TB drugs. Conclusion. Among patients with pulmonary TB and VH co-infection men aged 50–59 and women aged 60–69 years with unhealthy habits or underlying gastrointestinal or cardiovascular disease or type 2 diabetes mellitus prevailed. The typical manifestations of pulmonary TB in this category of patients were pulmonary tuberculoma, small destructive changes, and preserved susceptibility to TB drugs. Before TB treatment commencement the patients with pulmonary TB and VH co-infection had elevated aminotransferase levels, enlarged liver with signs of fibrosis.
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