Кислотно-основное равновесие слюны у больных с различной степенью тяжести течения острого панкреатита

Abstract

The purpose of the work. To study the change in acid-base balance in the oral cavity in various variants of the course of acute pancreatitis. Materials and methods. On the basis of GUZ "City Clinical Hospital No. 1" and GUZ "Regional Clinical Hospital" Chita for the period 2021-2023, a single-stage study was performed, which included 95 patients (n=95) suffering from acute pancreatitis of varying severity aged 15 to 80 years. At admission, the pH of saliva was measured using litmus strips from EKROSCHEM LLC, St. Petersburg. Statistical processing of the obtained results was carried out using the SPSS Statistics 11.0 program in compliance with the principles of statistical analysis adopted for research in biology and medicine. In order to assess the correlation and determine the closeness and direction of the correlation between the two features, Spearman's criterion was used. When comparing the study groups and the clinical comparison group, the Student's criterion with the Bonferroni correction was used. Results. As a result of the study, it was found that in patients with acute pancreatitis, the pH of saliva is shifted to the acidic side of 4.2-6.2 with an average value of 5.4 ±0.4. At the same time, in patients with acute pancreatitis, a shift in the acid-base balance of saliva towards its acidification was revealed as inflammatory and destructive changes in the pancreatic parenchyma increase. This established fact is of particular interest for the timely diagnosis of the severity of acute pancreatitis.