Особенности провоспалительного ответа при инфаркте миокарда у северных монголоидов на примере бурятской популяции

Abstract

The aim of the research. To study the biomarkers of inflammation in acute ST-elevation myocardial infarction (STEMI) in patients of the Buryat ethnic group in comparison with Russian patients. Material and methods. In 109 patients with acute STEMI of Buryat (n = 43) and Russian (n = 66) nationalities, as well as in 42 healthy donors (20 Buryats and 22 Russians), serum levels of high-sensitivity C-reactive protein, interleukin-1β (IL-1β ), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α), as well as IL-6/IL-10 and IL-8/IL-10 ratios were evaluated and compared between the ethnic groups with consideration for the clinical data and STEMI severity, as well as in the groups of healthy patients and those with STEMI. Results. The study groups did not differ in gender and age. Compared to healthy subjects in the STEMI group, the concentration of all inflammation biomarkers was higher regardless of ethnicity, with the exception of IL-1β, which significantly increased in Caucasians only. According to the results of comparative analysis, patients with STEMI of the Russian group matched to that of the Buryat, had higher levels of IL-1β (1.46 [0.41-3.67] and 0.02 [0.01- 1.12] pg/ml, respectively), TNF-α (2.1 [1.4-3.0] and 0.9 [0.4-2.2] pg/ml), IL-6/IL-10 ratios (4.9 [3.5-7.8] and 3.4 [1.7-6.7]) and IL-8/IL-10 (37.6 [8.1-63.4] and 11.9 [5.8-30.7]), troponin T (2.5 [0.19-15.5] and 0.38 [0.11-2.7] ng/ml), creatine phosphokinase-MB (29.4 [17.3-89] and 19.0 [12-26] IU/l), and lower body mass index (24.9 [22.5-28.4] and 27.3 [25.1-31.0] kg/m2) and left ventricular ejection fraction (51.5% [44-57] and 55.0% [50-58]). After adjustment for gender, age, and body mass index, the association with ethnicity remained significant for IL-1β (F for the general regression model was 5.28; p = 0.024) and the IL-6/IL-10 ratio (F = 4.43; p = 0.037). Conclusion. The pro-inflammatory response against the background of STEMI in the Buryat ethnic group as compared to the Russian one is characterised by lower levels of IL-1β, TNF-α as well as lower IL-6/IL-10 and IL-8/IL-10 ratios. After adjustment for gender, age, and body mass index, differences in ethnic groups remained significant for IL-1β and IL-6/IL-10, which indicates a less pronounced proinflammatory response in STEMI patients of the Buryat nationality.