ПЕРВИЧНЫЙ ОСТЕОАРТРИТ КОЛЕННЫХ СУСТАВОВ: СОВРЕМЕННЫЕ ПОДХОДЫ К РАННЕЙ ДИАГНОСТИКЕ И ОЦЕНКЕ КОМОРБИДНОГО ФОНА

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Objective: To study and evaluation of modern approaches to early diagnosis of primary knee osteoarthritis (PKOA), analysis of the frequency of comorbid diseases. Methods: The study included 98 patients with PKOA. In order to early diagnose the disease and determining prevalence and spectrum of the comorbid pathology, all patients were submitted to a comprehensive clinical laboratory and instrumental survey. Results: The most informative symptoms in the early diagnosis of PKOA were typical pain syndrome, sluggish synovitis and specific changes from the soft peri- and intraarticular tissues and bone structures of the knee joint, detected by MRI and arthrosonography (ASG). Comorbid diseases had 80.6% of the patients examined. Most commonly identified: cardiovascular pathology (CVP, 73.4%), metabolic syndrome (MS, 66.3%), gastrointestinal pathology (19.4%), type 2 diabetes mellitus (16.6%) and respiratory system diseases (12.2%). The majority of patients (66.2%) with developed of PKOA (of II and III stages) had two or more comorbid diseases. Conclusion: Early diagnosis of PKOA implies a comprehensive assessment of both subjective and objective symptoms of lesion, as well as MRI and ASG data. The most common and prognostically unfavorable comorbid diseases in patients with PKOA are CVP and MS, which have close associative relationship with the pathogenetic aspects of PKOA. Keywords: Primary osteoarthritis , early diagnosis, comorbidity, metabolic syndrome, cardiovascular pathology.