ДИНАМИКА УРОВНЯ КОРТИЗОЛА КРОВИ ПРИ КАРДИОХИРУРГИЧЕСКИХ ВМЕШАТЕЛЬСТВАХ В УСЛОВИЯХ ОБЩЕЙ МНОГОКОМПОНЕНТНОЙ СБАЛАНСИРОВАННОЙ АНЕСТЕЗИИ

Abstract

Objectives. The severity of the stress hormonal response during operations on heart valves in cardiopulmonary bypass (CPB) in multicomponent general anesthesia (GA) was evaluated by determining the level of plasma cortisol at different stages of the operation. Material and methods. Cortisol levels were studied in 24 patients who had undergone heart valve surgery in CPB. Results. At the stage 10 minutes before the start of the IC, cortisol levels were in the range of physiological values, at the end of the surgical intervention, cortisol increased by 3.3 (3.0; 5.2) times, compared with preoperative period. Conclusion. The level of plasma cortisol equal to 586.2 (410.7; 733.0) nmol/l at the patient's admission to the operating room, 426.3 (299.3; 597.0) nmol/l 10 minutes before the start of CPB, with its increase to 2170.6 (2077.0; 2427.2) nmol/l at the end of the operation, is the stress norm during operations on heart valves in GA.