ВЛИЯНИЕ БЛОКАДЫ ГАМКА-РЕЦЕПТОРОВ НА ИЗМЕНЕНИЯ ОРИЕНТИРОВОЧНО-ИССЛЕДОВАТЕЛЬСКОЙ АКТИВНОСТИ И ТРЕВОЖНОСТИ, ВЫЗВАННЫХ КОРТИКОЛИБЕРИНОМ

Abstract

The effect of the GABAA-receptor blockade with picrotoxin on the change in anxiety level under stress conditions induced by CRF was studied. In the T-maze test from the population of Wistar rats were selected animals with an active strategy of adaptive behavior, which in the elevated plus maze were divided into three groups: low anxiety (LA), high anxiety (HA) and mean anxiety (MA). Picrotoxin and CRF were injected intracerebroventricularly (ICV). The LA rats reacted to ICV administration of CRF with a decrease in the exploration activity, while the activity of the HA rats after the CRF injection was increased. The GABAA-receptor blockade with picrotoxin increased the exploration activity in HA and LA of rats, while simultaneously reducing the level of anxiety. After injection of CRF against of picrotoxin administration, the HA and LA rats demonstrated the decrease of exploration activity, and the level of anxiety increased only in LA rats. In animals from the MA group, the change in the behavioral response was observed only after the CRF and picrotoxin administration: the level of anxiety decreased, and the exploration activity increased. It is concluded that the vector of anxiety changes caused by CRF against the decrease in the activity of the stress-limiting GABA-ergic system depends on the initial psycho-emotional status of the animal.