Влияние низкомолекулярных пептидов, выделенных из кобыльего молока, на работоспособность крыс при физической нагрузке

Abstract

In an experiment on rats on the «Treadmill running» model, the performance indicators were studied, as well as the state of the antioxidant defense system, including the level of under-oxidized products in the blood serum, erythrocyte membranes and the mitochondrial fraction of the femoral muscle of animals against the background of 28-day intake of the fraction of non-molecular peptides isolated from mare's milk. In the experimental group, in comparison with the control animals, the running time on the treadmill on the 28th day increased by 73.5 %, while a positive trend of increasing the run time has been noted since the seventh day of training, gradually increasing to the 28th day of the training. The intake by animals of the enriched fraction of low molecular weight peptides against the background of physical activity was accompanied by a decrease in the MDA level in the membranes of erythrocytes by 25.3 %, and diene conjugates by 33.8 %, as well as the activation of superoxide dismutase and catalase in the membranes of erythrocytes. A similar change was found in the mitochondrial fraction of the femoral muscle of animals. The experimental group of rats showed a lower concentration of lactic acid in the blood serum by 40.6 %; and in the femoral muscle by 24.7 %. Pyretic acid content was not different from the initial values. These results substantiate the usefulness of low molecular weight peptides in the design of specialized products and dietary supplements for sports nutrition.