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Abstract
This study explores the peculiarities of biophysical properties in blood cells of the elderly under mechanical stress, applied in vitro, which, according to the literature data, triggers the signaling pathways engaged by purinergic receptor activation. Along with it, we detected a decrease in the stiffness of the cell surface of red blood cells, granulocytes, lymphocytes and platelets and the surface potential became more positive. Our findings could increase knowledge about the effect of mechanical deformation on leukocytes and platelets, which are the main regulators of homeostatic processes in the microvasculature, and on red blood cells involved in the regulation of vascular tone of arterioles and tissue oxygenation in the elderly.
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