МОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКАЯ ХАРАКТЕРИСТИКА МИКРОБИОТЫ ПАРОДОНТАЛЬНЫХ КАРМАНОВ У ПАЦИЕНТОВ С ХРОНИЧЕСКИМ ГЕНЕРАЛИЗОВАННЫМ ПАРОДОНТИТОМ, ПЕРЕНЕСШИХ COVID-19

Abstract

The aim of the study was to study the frequency of periodontal pathogens in patients with chronic forms of periodontitis who underwent COVID-19.
 Material and methods of research. Clinical and laboratory studies were conducted in a comparative aspect, depending on the presence/absence of a history of a new coronavirus infection. All patients who sought dental care for exacerbation of chronic generalized periodontitis (CGP) of mild and moderate severity were divided into 2 groups: 1 main group – 30 patients with CGP after a new coronavirus infection (after 4 months).
 Comparison group 2 – 30 patients with CGP who do not have a history of COVID-19, Patients of the compared observation groups (60 people) underwent a real-time PCR study of the contents of periodontal pockets.
 The results of the study. According to the results of molecular genetic screening, the DNA of six periodontal pathogenic bacteria was found in the contents of the periodontal pockets of the examined patients. Detection of bacteria associated with periodontitis (Porphyromonas endodontalis, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Treponema denticola, Fusobacterium nucleatum, Tannerella forsythia) showed no statistically significant differences in the prevalence of the studied bacteria in patients of the first and second groups. At the same time, the detected community of microorganisms Porphyromonas gingivalis and Porphyromonas endodontalis, characteristic of the most severe manifestations of periodontitis, was 17% more common among the examined patients who underwent COVID-19 than in patients without COVID-19.
 Thus, as a result of research, the presence of a relationship between the species composition of the microbiota of periodontal pockets and the presence of COVID-19 in the anamnesis has been shown.