ИЗУЧЕНИЕ ПЕРСПЕКТИВ ПРИМЕНЕНИЯ ИНТРАГАСТРАЛЬНЫХ КОКТЕЙЛЕЙ С ПРЕПАРАТАМИ КОРНЯ СОЛОДКИ РАЗНОГО ГАЗОВОГО СОСТАВА ПРИ COVID-19 НА ЭКСПЕРИМЕНТАЛЬНОЙ МОДЕЛИ ИММУНОПАТОЛОГИИ, ВЫЗВАННОЙ ГАММА ОБЛУЧЕНИЕМ ЖИВОТНЫХ

Abstract

This article is devoted to the results of an experimental study, the purpose of which was to clarify the mechanisms of action on the immune system of intragastric cocktails of different gas compositions (oxygen, carbon dioxide, and nitrogen), including in combination with licorice root preparations, with the subsequent prospect of use at different stages of rehabilitation of patients after COVID-19. The experimental model was male Wistar rats, whose acute external gamma irradiation causes a state of immunopathology similar to COVID-19. The data obtained indicated the presence of immunological correction effects under the influence of the studied agents. Moreover, it was noted that in cases of violations of the cellular component of immunity, preference should be given to nitrogen as a dispersion medium and carbon dioxide as a humoral medium, while the immunosuppressive effect is caused by cocktails with oxygen. Thus, it has been established that intragastric cocktails of different compositions differ from each other in the characteristics of the reactions that occur to their use, which in the future can be used at different stages of rehabilitation of patients with COVID-19 and for preventive purposes in the interpandemic period as differentiated methods of immunological correction. This requires additional clinical studies in accordance with the principles of evidence-based medicine.