РЕЗУЛЬТАТЫ ЗАЖИВЛЕНИЯ ОЖОГОВЫХ РАН С ПОМОЩЬЮ РАНЕВЫХ ПОКРЫТИЙ НА ОСНОВЕ БАКТЕРИАЛЬНОЙ ЦЕЛЛЮЛОЗЫ В ЭКСПЕРИМЕНТЕ

Abstract

Purpose of the study: in experimental studies to evaluate the effectiveness of healing and changes in the microbial spectrum of deep burn wounds during their treatment using wound dressings based on bacterial cellulose. Materials and methods. The object of the experimental studies was 60 Wistar rats, which formed a deep skin burn. All animals were divided into 3 groups, of which in group 1 (n=20) burn wounds were treated with pure wet bacterial cellulose (BC) wound dressings, in group 2 (n=20) BC was used with exposure to a 1% chlorhexidine and in group 3 (n=20) traditional treatment was performed with Levomekol ointment. On days 5, 10, 15, 20, 28 in the groups, the area of the wound surfaces, the dynamics of their decrease, and the microbial spectrum were studied. Results and conclusions. We registered that wound dressings based on wet bacterial cellulose, applied in pure form and with exposure to an antiseptic (1% chlorhexidine solution) for 28 days, increase the healing rate of burn wounds by an average of 18% compared to the traditional treatment group. The formed scab over the wound, when BC dries, provides the wound surface with a mechanical protective barrier that prevents injury to emerging dermal cells, microbial contamination and thereby increases the rate of epithelialization in a closed environment.