Abstract
Nowadays, due to the mass production of plastic products, the question of the negative impact of bisphenol A on the functioning of organs and systems is acute. However, the question of the effect of this xenobiotic on the functional state of the kidneys remains open. Currently, laser irradiation of various powers is intensively used to correct pathologies. However, its biochemical feathers of the impact on biological objects require detailed research. The work is aimed at the study of nephrotoxic effects of bisphenol A under the conditions of irradiation of animals with a diode laser. ВРА was administered per os daily for 3 days at a dose of 50 mg/kg body weight, which corresponded with LOAEL dose. Irradiation was performed for 2 min with a low-diode laser λ = 650 nm (50 mW, 1.5 J/cm2 and 12.5 mW/cm2). The functional state of the kidneys was performed based on the determination of urea and creatinine content in urine and serum. The content of primary and secondary products of the LP was determined in the kidneys. It is shown, that the administration of bisphenol A is accompanied by a decrease in urea in serum and urine, an increase in serum creatinine and a decrease in this metabolite in urine, which may indicate impaired renal and hepatic function due to the damage of this organ by contaminants due to induction lipid oxidation. This is expressed by an increase in the content of conjugated diene and TBA-active compounds in the kidneys. At the same time, under the irradiation of animals, the concentration of urea and creatinine in the serum decreases compared with the BPA group, and in the urine, these indicators increase. Such results may indicate the normalization of kidney function due to the corrective action of the laser. Thus, the introduction of BPA is accompanied by the induction of LPS processes, which leads to renal dysfunction, and irradiation of animals has a corrective effect of nephrotoxic effects of BPA.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
