Вклад полиморфизма генов сердечно-сосудистого риска в развитие метаболических нарушений у лиц, экспонированных винилхлоридом

Abstract

Introduction. Xenobiotics having the ability to change the gene expression level, the degree of which depends on the genotype include vinyl chloride (VС). Its impact causes changes in lipid metabolism proatherogenic IN character. Material and methods. A prospective cohort study was conducted In 120 males contacting with VС (mean age - 46.9±0.9 years; mean experience - 17.8±0.9 years). Lipid metabolism indices were studied; the results were compared with reference values. There were evaluated the genotypes of apolipoprotein C3 (ApoC3) C3238G rs5128, apolipoprotein E (ApoE) Leu28Pro rs769452 and lipoprotein lipase (LPL) Ser447Ter rs328. The significance of intergroup differences and correspondence of genotype frequencies to the Hardy – Weinberg law were assessed by the criterion χ 2 . Association of alleles or genotypes with a predisposition to disorders was assessed by odds ratio (OR). Results. In workers exposed to VC, there was an increase of the concentration of proatherogenic cholesterol fraction associated with carriage of genotype G/G polymorphic variant of the gene С3238G АРОС3, protective effect against this violation has each variant allele of a polymorphic variant of the gene LPL Ser447Ter. Carriers of any variant allele C/G or G/G polymorphic variant of the gene С3238G АРОС3 increases the likelihood of violations the antiatherogenic cholesterol fraction level, and any of the variant alleles T/C or C/C polymorphic variant of the gene Leu28Pro ApoE – reduces it. Probability of an increase the triglycerides level is elevated in the presence of both alleles of polymorphic gene variant of a gene С3238G АРОС3 and decreases – in the case of carriers of both polymorphic alleles of the gene variant Leu28Pro АроЕ. The presence of any variant allele of this polymorphic variant is significant in individuals with elevated total cholesterol. Conclusion. In terms of exposure to VC the probability of development of disorders of lipid metabolism-associated with genes rs5128 and rs769452. The gene rs328 has a protective effect.