ЦИТОГЕНЕТИЧЕСКАЯ ИНДИКАЦИЯ МУТАГЕННОГО ЭФФЕКТА В ДИАДАХ «МАТЬ – РЕБЕНОК» В ЗОНЕ ВЛИЯНИЯ ПРЕДПРИЯТИЙ АЛЮМИНИЕВОГО ПРОИЗВОДСТВА

Abstract

It is important to conduct cytogenetic monitoring to assess the level and dynamics of the frequency of cells with genome damage in parents and their children, formed in response to the impact of aluminum. Material and methods. In dyads «mother – child», the content of aluminum in urine was determined and a morphological evaluation of changes in buccal epitheliocytes was carried out. Results. It was found that in children and adults the concentration of aluminum in urine was 6,8 times higher than in the comparison groups and up to 5,5 times the reference level. The content of aluminum in urine in children is 1,3 times higher than in adults. The concentration of aluminum in urine (more than 0,0065 mg/dm3) is justified as an exposure marker. In children with a concentration of aluminum in urine at a level of 0,032–0,040 mg/dm3 and higher, the indicator indicators of genetic disorders are: an increase in the frequency of multinucleated cells, an integral index of cytogenetic action, and the frequency of cells with karyorexis. In adults with an aluminum concentration in urine of 0,021–0,033 mg/dm3 and higher markers of genetic disorders is the increased frequency of micronucleated cells and cells with karyorexis. Conclusion. In the dyads «mother – child», the spectrum and degree of severity of deviations in the indicators of genetic disorders in children relative to those of their mothers is growing.