ГЕМОДИНАМИКА В ТАЗОВЫХ КОНЕЧНОСТЯХ ПРИ ТРАВМЕ СПИННОГО МОЗГА В УСЛОВИЯХ ПРИМЕНЕНИЯ ПРОТИВОСПАЕЧНОГО ГИАЛУРОНСОДЕРЖАЩЕГО ГЕЛЯ

Abstract

It is possible to reduce the degree of systemic complications arising in response to spinal cord injury by providing timely medical care. Positive therapeutic effect of intrathecal administration of hyaluron gels is known for such injuries. In turn, these medications can be used as carriers of other medical substances. The aim of the research is to study hemodynamics in hind limbs in case of traumatic spinal cord injury using an anti-adhesion gel which contains Na-carboxymethyl cellulose. Rats’ spinal cord injury at the level of the thoracic section of the spine was simulated and a hyaluronic-containing anti-adhesion absorbable gel was injected into the injury area. Hemodynamics and temperature response of pelvic limb tissues were studied. Heart rate dynamics and general body temperature were assessed. The quantitative data were compared with the physiological norm. The animals were observed for 90 days. No heart rhythm disturbances were noted. During the experiment, hyperthermy of central genesis was recorded, which was characterized by an increase of the total body temperature to a maximum of 37.11 ± 0.6 ° C (p = 0.004) and local temperature - up to 34.48 ± 2.24 ° C (p = 0.002). The phenomena of vasodilatation of the arteries were observed, which were more pronounced after 60 days of the experiment. Further on, the visco-elastic properties of the vessels improved. Difficulties in venous outflow in the created conditions were not found. According to available literature data, when modeling a spinal cord injury without application of antiadhesion hyaluronic medications, vascular disorders are more explicit. Conclusion. The application of a hyaluronic anti-adhesion gel for traumatic spinal cord injury can reduce the intensity of emerging pathological conditions.